Interface-promoted Assembly and Disassembly Processes for Rapid Manufacture and Transport of Complex Hybrid Nanomaterials
The intimate combination of inorganic nanoparticles and organic polymers within nanoscopic packages of controlled sizes and shapes includes many challenges with the processes for their production and many opportunities for unique materials properties. Organic polymers are typically considered as plastics and they have physical and mechanical properties that allow them to serve common roles, such as elastic materials (clothing, tents, parachutes, etc.), containment vessels (cups, plastic bags, etc.), and high technology needs, such as optical materials (eye glasses, OLED devices, etc.), engineering materials (airplane parts, football helmets, etc.), among many others. Inorganic nanoparticles are typically rigid and often possess characteristics of magnetism, optical signaling or catalytic reactivity. This project will develop computational methods to guide approaches to rapidly discover and manufacture hybrid inorganic-organic nanostructured objects (HIONs) possessing complexity of compositions, structures, properties and functions.
Publications
Elucidation of Substantial Differences in Ring-Opening Polymerization Outcomes from Subtle Variation of Glucose Carbonate-Based Monomer Substitution Patterns and Substituent Types
Y. Shen, M. Leng, Y. Yang, S. K. Boopathi, G. Sun, and K. L. Wooley
7/6/2023
Complexities of Regioselective Ring-Opening vs Transcarbonylation-Driven Structural Metamorphosis during Organocatalytic Polymerizations of Five-Membered Cyclic Carbonate Glucose Monomers
Y. Shen, X. Yang, Y. Song, D. K. Tran, H. Wang, J. Wilson, M. Dong, M. Vazquez, G. Sun, and K. L. Wooley
1/14/2022
Machine Learning Enhanced Computational Reverse Engineering Analysis for Scattering Experiments (CREASE) to Determine Structures in Amphiphilic Polymer Solutions
M. G. Wessels, and A. Jayaraman
7/23/2021
Morphologic Design of Silver-Bearing Sugar-Based Polymer Nanoparticles for Uroepithelial Cell Binding and Antimicrobial Delivery
Y. Song, M. Elsabahy, C. A. Collins, S. Khan, R. Li, T. N. Hreha, Y. Shen, Y. Lin, R. A. Letteri, L. Su, M. Dong, F. Zhang, D. A. Hunstad, and K. L. Wooley
6/11/2021
Morphologic design of sugar-based polymer nanoparticles for delivery of antidiabetic peptides
M. Elsabahy, Y. Song, N. G. Eissa, S. Khan, M. A. Hamad, and K. L. Wooley
6/1/2021
Polypeptide organic radical batteries
T. P. Nguyen, A. D. Easley, N. Kang, S. Khan, S. Lim, Y. H. Rezenom, S. Wang, D. K. Tran, J. Fan, R. A. Letteri, X. He, L. Su, C. Yu, J. L. Lutkenhaus, and K. L. Wooley
5/5/2021
Computational Reverse-Engineering Analysis of Scattering Experiments (CREASE) on Amphiphilic Block Polymer Solutions: Cylindrical and Fibrillar Assembly
M. G. Wessels, and A. Jayaraman
1/5/2021
Invoking Side-Chain Functionality for the Mediation of Regioselectivity during Ring-Opening Polymerization of Glucose Carbonates
Y. Song, X. Yang, Y. Shen, M. Dong, Y. Lin, M. B. Hall, and K. L. Wooley
9/23/2020
Hierarchical Self-Assembly of Poly(d -glucose carbonate) Amphiphilic Block Copolymers in Mixed Solvents
J. Y. Lee, Y. Song, M. G. Wessels, A. Jayaraman, K. L. Wooley, and D. J. Pochan
9/21/2020
Anionic nanoparticle and microplastic non-exponential distributions from source scale with grain size in environmental granular media
W. P. Johnson, A. Rasmuson, C. Ron, B. Erickson, K. VanNess, D. Bolster, and B. Peters
9/1/2020
A Tale of Drug-Carrier Optimization: Controlling Stimuli Sensitivity via Nanoparticle Hydrophobicity through Drug Loading
Y. Lin, S. Khan, Y. Song, M. Dong, Y. Shen, D. K. Tran, C. Pang, F. Zhang, and K. L. Wooley
8/10/2020
Quantitative Linking of Nanoscale Interactions to Continuum-Scale Nanoparticle and Microplastic Transport in Environmental Granular Media
W. P. Johnson
5/27/2020
Erythrocyte-Membrane-Camouflaged Nanocarriers with Tunable Paclitaxel Release Kinetics via Macromolecular Stereocomplexation
Y. Lin, M. Elsabahy, S. Khan, F. Zhang, Y. Song, M. Dong, R. Li, J. Smolen, R. A. Letteri, L. Su, and K. L. Wooley
4/30/2020
Self-assembly of amphiphilic polymers of varying architectures near attractive surfaces
M. G. Wessels, and A. Jayaraman
1/1/2020
Complementary colloid and collector nanoscale heterogeneity explains microparticle retention under unfavorable conditions
C. A. Ron, and W. P. Johnson
1/1/2020
Degradable sugar-based magnetic hybrid nanoparticles for recovery of crude oil from aqueous environments
M. Dong, Y. Song, H. Wang, L. Su, Y. Shen, D. K. Tran, R. A. Letteri, J. A. Flores, Y. Lin, J. Li, and K. L. Wooley
1/1/2020
In Situ Production of Ag/Polymer Asymmetric Nanoparticles via a Powerful Light-Driven Technique
R. Li, H. Wang, Y. Song, Y. Lin, M. Dong, Y. Shen, S. Khan, S. Zhang, J. Fan, F. Zhang, L. Su, and K. L. Wooley
12/10/2019
Polymers with controlled assembly and rigidity made with click-functional peptide bundles
D. Wu, N. Sinha, J. Lee, B. P. Sutherland, N. I. Halaszynski, Y. Tian, J. Caplan, H. V. Zhang, J. G. Saven, C. J. Kloxin, and D. J. Pochan
10/30/2019
Computational Reverse-Engineering Analysis for Scattering Experiments on Amphiphilic Block Polymer Solutions
D. J. Beltran-Villegas, M. G. Wessels, J. Y. Lee, Y. Song, K. L. Wooley, D. J. Pochan, and A. Jayaraman
9/9/2019
Theory-Guided Targeted Delivery of Nanoparticles in Advective Environmental Porous Media
C. A. Ron, M. Dong, K. L. Wooley, and W. P. Johnson
8/30/2019
Experiments and Simulations of Complex Sugar-Based Coil−Brush Block Polymer Nanoassemblies in Aqueous Solution
M. Dong, M. G. Wessels, J. Y. Lee, L. Su, H. Wang, R. A. Letteri, Y. Song, Y. Lin, Y. Chen, R. Li, D. J. Pochan, A. Jayaraman, and K. L. Wooley
4/16/2019
Molecular dynamics simulation study of linear, bottlebrush, and star-like amphiphilic block polymer assembly in solution
M. G. Wessels, and A. Jayaraman
1/1/2019
How nanoscale surface heterogeneity impacts transport of nano- to micro-particles on surfaces under unfavorable attachment conditions
C. A. Ron, K. VanNess, A. Rasmuson, and W. P. Johnson
1/1/2019
Advancing the Development of Highly-Functionalizable Glucose-Based Polycarbonates by Tuning of the Glass Transition Temperature
Y. Song, X. Ji, M. Dong, R. Li, Y. Lin, H. Wang, and K. L. Wooley
11/12/2018
Functional, Degradable Zwitterionic Polyphosphoesters as Biocompatible Coating Materials for Metal Nanostructures
R. Li, M. Elsabahy, Y. Song, H. Wang, L. Su, R. A. Letteri, S. Khan, G. S. Heo, G. Sun, Y. Liu, and K. L. Wooley
10/22/2018
Molecular Dynamics Simulation and PRISM Theory Study of Assembly in Solutions of Amphiphilic Bottlebrush Block Copolymers
I. Lyubimov, M. G. Wessels, and A. Jayaraman
9/20/2018
Construction of nanostructures in aqueous solution from amphiphilic glucose‐derived polycarbonates
S. Osumi, S. E. Felder, H. Wang, Y. Lin, M. Dong, and K. L. Wooley
9/19/2018
Assembly of Amphiphilic Block Copolymers and Nanoparticles in Solution: Coarse-Grained Molecular Simulation Study
D. J. Beltran-Villegas, and A. Jayaraman
2/5/2018
Co-assembly of sugar-based amphiphilic block polymers to achieve nanoparticles with tunable morphology, size, surface charge, and acid-responsive behavior
Y. Lin, L. Su, J. Smolen, R. Li, Y. Song, H. Wang, M. Dong, and K. L. Wooley
1/1/2018
Molecular dynamics simulations and PRISM theory study of solutions of nanoparticles and triblock copolymers with solvophobic end blocks
D. J. Beltran-Villegas, I. Lyubimov, and A. Jayaraman
1/1/2018
PRISM Theory Study of Amphiphilic Block Copolymer Solutions with Varying Copolymer Sequence and Composition
I. Lyubimov, D. J. Beltran-Villegas, and A. Jayaraman
9/7/2017
Crystallization-driven assembly of fully degradable, natural product-based poly(l-lactide)-block-poly(α-d-glucose carbonate)s in aqueous solution
Y. Song, Y. Chen, L. Su, R. Li, R. A. Letteri, and K. L. Wooley
7/1/2017
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Research Highlights
Theory-guided Targeted Delivery of Nanoparticles in Advective Environmental Porous Media
William P. Johnson and Karen L. Wooley
11/14/2019
Degradable Block Copolymers
Karen Wooley (Texas A&M University)
3/20/2018
Polymer-based Outreach Activities
Karen Wooley (Texas A&M University)
3/20/2018
View All Highlights