Generation, Functionalization and Distribution of de novo Designed Protein Nanomaterials
Proteins are large molecules that have complex three-dimensional (3D) structures that give them sophisticated cellular functions. To provide access to complex protein structures not found in nature, Professors Baker and King of the University of Washington and Professor Yeates of University of California Los Angeles collaborate to compute and precisely control the assembly of proteins into 3D architectures. The research team shares these capabilities with the engineering and scientific communities and constructs a Designed Protein Nanomaterial (DPN) database to enable others to rapidly build on these advances. The long-term goal is to allow predictable design of protein-based materials for use in a wide range of applications such as targeted drug delivery, functional materials for energy conversion, and other chemical technologies. The interdisciplinary project provides excellent research training opportunities to postdoctoral researchers and students.
Publications
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Research Highlights
Increasing Computational Protein Design Literacy through Cohort-based Learning for Undergraduate Students
                  
                   David Baker and Neil King (U. Washington)
                    10/25/2024
                  Computational Design of Mechanically Coupled Axle-rotor Protein Assemblies
                  
                   Neil King and David Baker (U. Washington)
                    10/25/2024
                  Blueprinting Extendable Nanomaterials with Standardized Protein Blocks
                  
                   David Baker (U. Washington)
                    10/25/2024